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The effect of pridoxamine on erectile function in diabetic rats

Xiaofeng Pu

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Abstract

Objective:To investigate the effect of pridoxamine on erectile function in diabetic rats.Methods:Male adult Sprague-Dawley rats were induced for diabetes by an intraperitoneal injection of streptozotocin,then randomly divided into DM group and DM+PM group.The rats in DM+PM group were treated with pridoxamine at a dosage of 200mg/kg through a gastric perfusion every day.Twelve weeks later the erectile function of all these rats were evaluated,and their penises tissues were harvested.The NO,NOS,and cGMP levels in corpus cavernosum were measured.Results:The diabetic rat model was successfully established.The erectile function was much better in normal control group(group C,100%) and DM+PM group(71.4%)than in DM group(46.2%)(P0.05).The NO level in DM group was significantly decreased(3.23±0.28)μmol/gprot,compared with group C(7.82±0.77)μmol/gprot and DM+PM group(6.47±0.54)μmol/gprot(P0.05).The NOS level in group C(2.00±0.30)U/mgprot and DM+PM group(1.07±0.15)U/mgprot was both much higher than in DM group(0.69±0.11)U/mgprot(P0.05).The cGMP content in corpus cavemosum was markedly decreased in DM group(36.15±1.94)pmol/ml,compared with group C(54.19±2.62)pmol/ml and DM+PM group(50.57±1.20)pmol/ml,(P0.05).Conclusion:The pridoxamine has some effect of L-Arg-NO-cGMP pathway on diabetic rats’penis tissues,and may play some role in protecting the harm to erectile function caused by diabeties.

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Objective:To investigate the effect of pridoxamine on erectile function in diabetic rats.Methods:Male adult Sprague-Dawley rats were induced for diabetes by an intraperitoneal injection of streptozotocin,then randomly divided into DM group and DM+PM group.The rats in DM+PM group were treated with pridoxamine at a dosage of 200mg/kg through a gastric perfusion every day.Twelve weeks later the erectile function of all these rats were evaluated,and their penises tissues were harvested.The NO,NOS,and cGMP levels in corpus cavernosum were measured.Results:The diabetic rat model was successfully established.The erectile function was much better in normal control group(group C,100%) and DM+PM group(71.4%)than in DM group(46.2%)(P0.05).The NO level in DM group was significantly decreased(3.23±0.28)μmol/gprot,compared with group C(7.82±0.77)μmol/gprot and DM+PM group(6.47±0.54)μmol/gprot(P0.05).The NOS level in group C(2.00±0.30)U/mgprot and DM+PM group(1.07±0.15)U/mgprot was both much higher than in DM group(0.69±0.11)U/mgprot(P0.05).The cGMP content in corpus cavemosum was markedly decreased in DM group(36.15±1.94)pmol/ml,compared with group C(54.19±2.62)pmol/ml and DM+PM group(50.57±1.20)pmol/ml,(P0.05).Conclusion:The pridoxamine has some effect of L-Arg-NO-cGMP pathway on diabetic rats’penis tissues,and may play some role in protecting the harm to erectile function caused by diabeties.

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Available abstract

Objective:To investigate the effect of pridoxamine on erectile function in diabetic rats.Methods:Male adult Sprague-Dawley rats were induced for diabetes by an intraperitoneal injection of streptozotocin,then randomly divided into DM group and DM+PM group.The rats in DM+PM group were treated with pridoxamine at a dosage of 200mg/kg through a gastric perfusion every day.Twelve weeks later the erectile function of all these rats were evaluated,and their penises tissues were harvested.The NO,NOS,and cGMP levels in corpus cavernosum were measured.Results:The diabetic rat model was successfully established.The erectile function was much better in normal control group(group C,100%) and DM+PM group(71.4%)than in DM group(46.2%)(P0.05).The NO level in DM group was significantly decreased(3.23±0.28)μmol/gprot,compared with group C(7.82±0.77)μmol/gprot and DM+PM group(6.47±0.54)μmol/gprot(P0.05).The NOS level in group C(2.00±0.30)U/mgprot and DM+PM group(1.07±0.15)U/mgprot was both much higher than in DM group(0.69±0.11)U/mgprot(P0.05).The cGMP content in corpus cavemosum was markedly decreased in DM group(36.15±1.94)pmol/ml,compared with group C(54.19±2.62)pmol/ml and DM+PM group(50.57±1.20)pmol/ml,(P0.05).Conclusion:The pridoxamine has some effect of L-Arg-NO-cGMP pathway on diabetic rats’penis tissues,and may play some role in protecting the harm to erectile function caused by diabeties.

Key concepts: Internal medicine, Endocrinology, Erectile dysfunction, Erectile function, Streptozotocin, Penis, Diabetes mellitus, Medicine

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