Analysis of Y chromosome microdeletions and gonadal hormone level in 251 infertile men

Objective: To screen for Y chromosome microdeletions in patients with severe oligospermia or azoospermia,and explore the levels of gonadal hormone about patients of Y chromosome microdeletion.Methods: Y chromosome microdeletions among 183 patients with severe oligospermia and 68 patients with azoospermia were analyzed,and the levels of gonadal hormone were detected by chemiluminescent met-hod.Results: Out of 251 patients,21 were found with Y chromosome microdeletion,with a rate of 8.37%,of which 15 were severe oligospermia,6 were azoospermia.All the deletion type were 1 case(4.76%) in AZFb,2 cases(9.52%) in AZFb+AZFc,15 cases(71.43%) in AZFc,2 cases(9.52%) in AZFc+AZFd,,1 case(4.76%) in AZFd.In gonadal hormone testing,level of FSH in Y chromosome microdeletions groups was significantly increased(P0.05).Conclusion: Y chromosome microdeletion is one of main genetic factors in infertile men,most of the deletions happen in AZFc.In order to decide the therapy,it is necessary to detect the level of gonadal hormone and analyse the factors of infertility for these patients.