Expression and significance of Ki-67,ER and PR in adenomyosis

[Objective] To investigate the expression of Ki-67,ER and PR in adenomyosis and biological significance.[Methods] The expression of Ki-67,ER and PR was detected by immuno-histochemical method in adenomyosis,atypical hyperplasia,endometrial carcinoma and normal endometrium.[Results] The expression of Ki-67 in ectopic endometrium(40/46) was higher than that in eutopic endometrium in adenomyosis(30/46),P0.05.The expression of Ki-67 was much higher in adenomyosis(40/46),atypical hyperplasia(21/23),endometrial carcinoma(20/23) than that in normal endometrium(2/22),P0.01.The expression of ER and PR in glandular tissue of eutopic endometrium was 41/46 and 41/46,higher tnan that in ectopic endometrium 32/46 and 33/46.The expression of PR in ectopic endometrim stroma(30/46) was lower than that in eutopic endometrium stroma(44/46),P0.01.[Conclusions] Abnormal expression of Ki-67 might be involved in proliferation and pathogenesis in adenomyosis,being similar biological behavior to endometrial carcinoma.The variation of expression level of ER,PR and Ki-67 may be related to invasive growth of endometrium.