The Effect of ZhongFeiHeJi Regulate the Expression of MMP-9/TIMP-A in Lung Tissue of Rats With Radioactive Injury of Lungs

Objective:To study the effect of ZhongFeiHeJi acting on the expressing of MMP-9 /TIMP-1 in the lung tissue of rat with radiation-induced pulmonary injury lung tissue.Methods:The rats in ZhongFeiHeJi group were poured with ZhongFeiHeJi after 90 Wistar rats were randomly divided into the normal group,the model group,the ZhongFeiHeJi group,and the rat model of radiation-induced pulmonary injury was copied by radiated with 6MV-X ray linear accelerator for 25Gy dose.After 8 weeks,the lungs of rats' were harvested out,calculated the lung coefficient,the sliced and detect the express of MMP-1 and TIMP-9 by the immunohistochemistry.Results:Comparing with the MMP-9 and TIMP-1 in the lung tissues of the model group,the ZhongFeiHeJi decreases the expression of MMP-9,and TIMP-1 increased after 8 weeks.Conclusion:ZhongFeiHeJi can be prevented in pulmonary fibrosis,and has a role in the radiation-induced lung injury's prevention and treatment.