2001•Unpublished venueRequires access

Effects of adenosine receptor antagonist on isoflurane-induced myocardial protection in isolated rat hearts

Hong Zhang

Abstract

Objective:To determine whether isoflurane induced myocardial protection is mediated by adenosine receptor subtype A 1 Methods: Five groups ( n =8) of isolated rat hearts were studied in the Langendorff apparatus The hearts were subjected to 30min global ischemia and 120min reperfusion DP, EDP, LV+dp/dt max and LV dp/dt min were recorded and analyzed after administrating isoflurane and (or) adenosine receptor antagonist (DPCPX) Results: Isoflurane significantly decreased EDP and improved the recoveries of DP, LV+dp/dt max and LV dp/dt min during reperfusion compared with control groups( P 0 05) DPCPX administrated before or after the global ischemia couldn′t attenuate the protection of isoflurane ( P 0 05) Conclusion: Isoflurane enhances the post ischemic functional recovery of isolated rat heart and A 1 receptors are not involved in isoflurane induced myocardial protection

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Key concepts: Isoflurane, Adenosine, Antagonist, Medicine, Ischemia, Adenosine receptor antagonist, Receptor antagonist, Anesthesia