The detect signification of lactoferrin in tears of patients with dry eye

Objective To investigate the relationship of lactoferrin in tear and dry eye,and meanings of lactoferrin for dry eye.Methods Lactoferrin in tear of forty eyes of 40 cases with dry eye and thirty-five eyes of 35 normal persons were tested by Radial Immunodiffusion Assay.Statistic analysis was used to study the correlation between LF and SchirmerⅠtest,BUT and age.Results The concentration of LF was significantly decreased in tears of dry eye compared with control subjects(P0.0005).There is apositive relationship between LF in tears and SchirmerⅠtest,BUT of non-Sjogren's syndrome(r=0.48,0.78,P0.005).While there is a negative relationship between LF and age(r=-0.74,P0.005).Conclusion It is one of the pathogeny of dry eye that the decreasing of lactoferrin in tears.When treat non-Sjogren's sundrome,it is not enough to supply artificial tears,LF with bilolgic actibity is one of the most important measure.