Analysis on chromosomal karyotype of 110 children receiving genetic counseling

Objective:To explore the frequency and type of abnormal chromosomal karyotype of 110 children receiving genetic counseling.Methods:The children diagnosed as mongolism,development retardation,mental retardation and congenital malformations received chromosomal karyotype analysis in peripheral blood.Results:36 children were found with abnormal chromosomal karyotype,the detection rate was 32.73%,including 22 children(61.11%) with abnormal autosome karyotype,accounting for 20.00%;14 children(38.89%) with abnormal sex chromosome karyotype,accounting for 12.73%.Conclusion:Chromosomal aberration is the main cause of birth defects,the children suspicious of genetic syndrome should receive chromosomal examination.