RELATIONSHIP BETWEEN SERUM PANEL REACTIVE ANTIBODY OF RECIPIENTS AND EARLY POSTOPERATIVE REJECTION IN RENAL TRANSPLANTATION

Objective To study the association of the level of serum panel reactive antibody (PRA) in recipients with early rejection after kidney transplantation. Methods The serum level of PRA in 256 recipients were detected preoperatively,its correlation with early-postoperative rejections,i.e. hyper-acute,accelerated,and acute rejection,were analyzed. Results The differences of early-postoperative rejection rates among PRA negative group,lightly-sensitive group and hyper-sensitive group were with highly statistical significance (χ2=78.23,P0.01). PRA positive rate in male was lower than in female (χ2=14.18,P0.01); that in the group without a history of blood transfusion was lower than that in those with transfusion (χ2=5.39,P0.05); no difference was noted of PRA between those with a history of gestation or without (χ2=0.66,P0.05). PRA positive rate in those underwent twice transplantations was higher than those underwent procedure for the first time (χ2=20.10,P0.01). Conclusion Blood transfusion and retransplantation are the risk factors of PRA positive. The rate of early-postoperative rejection increases along with the elevation of PRA level. Recipients with low serum PRA may reduce early rejection and improve the survival of the patient and kidney.