Inhibition effect of safflor yellow on H_(22) solid tumor in mice

Objective To observe the suppression role of different doses of safflor yellow to liver cancer tumors in mice H22 tumor-burdened,preliminarily discuss its antitumor mechanism in vivo.Methods Made the tumor-bearing mice model,and randomly divided the mice into five experimental groups,SY high,medium and low doses groups,positive control cytoxan group and model control group.In injection drug respectively eight days put the animals to death,draw materials.Determined the tumor growth inhibition ratio(IR,%),extended life rate(%),thymus index,spleen index,liver/body ratio,lung/body ratio,and weight changes before and after drug used.Results The general situation and weight growth of the SY mice were better than the positive control cytoxan group.Low,moderate and high dose treatment groups showed inhibition H22 solid tumor activity with inhibition ratio 36.00%,38.86%,34.29%,and tumor weight compared with model control group were significant difference(P 0.01).The spleen index and thymus index of SY each dose group all had significant difference compared with the CTX group(P 0.01),and the liver/body ratio,lung/body ratio of small dose group was significant different compared with the CTX group(P 0.01),showed that SY had small damage to the body than CTX.Conclusion Safflor yellow can suppress mouse H22 grafting tumor growth conspicuously,and its side effect is less than the positive control cytoxan group.