ESTABLISHMENT OF AN INTERVERTEBRAL DISC DEGENERATION MODEL IN GOAT

Objective To establish an intervertebral disc degenerative model in goat. Methods Sixteen goats were evenly divided into four groups in random.In groups A,B,and C,puncture needles with 16 G,18 G,or 27 G were used to induce injuries to the left anterolateral anulus fibrosus of the experimental animals respectively.In group D,the dics were exposed operatively but not injured.Radiological examination and histological study were performed both before and 3,6,12 and 24 weeks after the experiment. Results No significant changes were found in groups C and D.Slow and progressive intervertebral disc degeneration was found in groups A and B. Conclusion A relatively ideal goat slow-moving intervertebral disc degenerative model can be made by the method used in this study.