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2009•China Animal Husbandry & Veterinary MedicineRequires access

Advances on Five Related Genes with Delayed Puberty in Mammals

Zhang Yingjie

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Abstract

Sexual maturation of humans and mammals was driven by an intermittent discharge of gonadotropin-releasing hormone(GnRH) generated by a network of hypothalamic neurons known as the GnRH pulse generator.Reproductive disorder will present once GnRH release was suppressed or destroyed,which will result in hypothalamic hypogonadism.As for humans,this disorder presents azoospermatism and amenorrhea resulted from hypoevolutismus and sex hypoplasia.Animals affected by hypothalamic hypogonadism present puberty delay and reproductive capacity degression.Mutations of the genes encoding gonadotrophins and their receptors may cause delayed puberty.This review briefly introduced the relationships between GPR54,GnRH/GnRHR,FSH/FSHR,LH/LHR genes and delayed puberty in mammals.

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What this paper is about

Sexual maturation of humans and mammals was driven by an intermittent discharge of gonadotropin-releasing hormone(GnRH) generated by a network of hypothalamic neurons known as the GnRH pulse generator.Reproductive disorder will present once GnRH release was suppressed or destroyed,which will result in hypothalamic hypogonadism.As for humans,this disorder presents azoospermatism and amenorrhea resulted from hypoevolutismus and sex hypoplasia.Animals affected by hypothalamic hypogonadism present puberty delay and reproductive capacity degression.Mutations of the genes encoding gonadotrophins and their receptors may cause delayed puberty.This review briefly introduced the relationships between GPR54,GnRH/GnRHR,FSH/FSHR,LH/LHR genes and delayed puberty in mammals.

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Available abstract

Sexual maturation of humans and mammals was driven by an intermittent discharge of gonadotropin-releasing hormone(GnRH) generated by a network of hypothalamic neurons known as the GnRH pulse generator.Reproductive disorder will present once GnRH release was suppressed or destroyed,which will result in hypothalamic hypogonadism.As for humans,this disorder presents azoospermatism and amenorrhea resulted from hypoevolutismus and sex hypoplasia.Animals affected by hypothalamic hypogonadism present puberty delay and reproductive capacity degression.Mutations of the genes encoding gonadotrophins and their receptors may cause delayed puberty.This review briefly introduced the relationships between GPR54,GnRH/GnRHR,FSH/FSHR,LH/LHR genes and delayed puberty in mammals.

Key concepts: GNRHR, Delayed puberty, Hypothalamic disease, Gonadotropin-releasing hormone, Internal medicine, Endocrinology, Biology, Sexual maturity

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