Level distribution of estrogen receptor and progesterone receptor in human uterus of menopause and adenomyosis group

Objective To compare the gradient distribution of estrogen and progesterone receptor in the whole layers of the uterus(mucous,superficial myometrium,deep myometrium layer and subserious layers) by the expression of estrogen and progesterone receptors.Methods To evaluate the distribution and intensity of estrogen receptor(ER) and progesterone receptor(PR) stained in the various part of human endometrium and myometrium,two different diseases were chosen in the menopause and adenomyosis group.Immuno-histochemical study was performed on ER and PR in the whole layers(mucous layer,superficial myometrium layer,and deep myometrium layer).Results There was significant difference in distribution of ER and PR between endometrium and other layers(P0.01) in menopause group.There was significant difference in distribution of ER and PR between subserous and other layers(P=0.000) in adenomyosis group.Conclusions In menopause ER and PR levels is maximum in the endometrium.So the endometrial abalation is effective for the tamoxifen-treated breast cancer patients.