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2003•Acta Universitatis Medicinalis Secondae ShanghaiRequires access

Study on Relationship Between Epidermal Growth Factor Receptor and Uterine Leiomyoma

Qi-de Lin

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Abstract

Objective To investigate the relationship between EGF - R and uterine leiomyoma. Methods The ER, PR contents and EGF - R levels were determined by immuno - histochemistry and FCM method in 28 patients with uterine leiomyoma and myometrium (control). Results The ER, PR contents and EGF - R levels in leiomyoma were significantly higher than those in the myometrium ( P 0.01); There was positive correlation of ER/PR content versus EGF - R level in uterine leiomyoma. Conclusion The EGF -R may play an imptortant role in leiomyoma enlargement; estrogen and progesterone may affect the expression of EGF - R in leiomyoma.

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What this paper is about

Objective To investigate the relationship between EGF - R and uterine leiomyoma. Methods The ER, PR contents and EGF - R levels were determined by immuno - histochemistry and FCM method in 28 patients with uterine leiomyoma and myometrium (control). Results The ER, PR contents and EGF - R levels in leiomyoma were significantly higher than those in the myometrium ( P 0.01); There was positive correlation of ER/PR content versus EGF - R level in uterine leiomyoma. Conclusion The EGF -R may play an imptortant role in leiomyoma enlargement; estrogen and progesterone may affect the expression of EGF - R in leiomyoma.

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Available abstract

Objective To investigate the relationship between EGF - R and uterine leiomyoma. Methods The ER, PR contents and EGF - R levels were determined by immuno - histochemistry and FCM method in 28 patients with uterine leiomyoma and myometrium (control). Results The ER, PR contents and EGF - R levels in leiomyoma were significantly higher than those in the myometrium ( P 0.01); There was positive correlation of ER/PR content versus EGF - R level in uterine leiomyoma. Conclusion The EGF -R may play an imptortant role in leiomyoma enlargement; estrogen and progesterone may affect the expression of EGF - R in leiomyoma.

Key concepts: Myometrium, Leiomyoma, Uterine leiomyoma, Epidermal growth factor, Uterus, Internal medicine, Estrogen receptor, Endocrinology

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