2007•Chongqing Yike Daxue xuebaoRequires access
Effect of Hypoxia-inducible factor-1 alpha on the radiosensitivity of rat cervical carcinoma
Liu Fang-xin
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Abstract
Objective:To study the effect of Hypoxia-inducible factor-1 alpha(HIF-1α)on the radiosensitivity of rat cervical carcinoma and discuss the possible mechanism.Methods:The transplantation tumor model of cervical carcinoma was established. 77 rats were randomly divided into five groups:control group,the large fraction irradiation group,the small fraction irradiation group,the large fraction irradiation combining HBO group and the low dose irradiation combining HBO group.Expressions of HIF-1α and bcl-2 in transplantation tumor after treatment were detected by immunohistochemical staining,and the tumor inhibitory rate by the change of tumor volume.The correlation between expressions of HIF-1 α and bcl-2(and tumor inhibitory rate)was also observed.Results:Expression of HIF-1 α and carcinoma growth inhibitory rate showed a reverse correlation(r=-5.147,P0.05).No correlation was found between the expression of HIF-1 α and bcl-2.Conclusions:Inhibiting the HIF-1α expression could effectively promote the radiosensitivity of rat cervical carcinoma without impacting the expression of Bcl-2.