2011•Chongqing Yike Daxue xuebaoRequires access
Relationship between GGT mRNA-H subtype expression and the survival of HCC patients after radical mastectomy
Yong Xie
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Abstract
Objective:To evaluate the relationship between GGT mRNA-H subtype expression and the survival of HCC patients after radical mastectomy.Methods:67 patients with HCC were enrolled in this study.On the surgery day,10 ml peripheral venous blood was drawn from each patient in the morning,PCR used to detect the GGT mRNA-H subtype expression.AFP level were also detected by radioimmunoassay.Results:The 1,3,5-year survival rates of the 67 HCC patients were 71.5%,35.1% and 18.7% respectively,of which 79.5%,42.3% and 22.1% were found respectively in the negative expression of GGT mRNA-H subtype,and 65.5%,24.1% and 11.7% found respectively in the positive expression(χ2=3.014,P=0.021).Cox model showed that GGT mRNA-H had more impact on prognosis than the AFP(OR=1.672 vs OR=1.145).Conclusion:Peripheral blood cell GGTmRNA-H subtype expression detection is a reliable indicator to predict the prognosis of primary liver cancer patients,and it's better than AFP testing.