2007•Suzhou Daxue xuebao. Yixue banRequires access
Changes of Hemodynamics After Cerebral Ischemia-reperfusion Injury in Rats
Wang Yong-tang
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Abstract
Objective To investigate the changes of hemodynamics and cerebral blood flow after cerebral ischemia-reperfusion injurg in rats. Methods With thread method, cerebral ischemia-reperfusion injury model of rats was established. The rats were randomly divided into the groups as sham operated control group and the groups of ischemia-reperfusion for 3 , 6 , 12, 24 h,6 animals per group. Changes of regional blood flow in hippocampus(MAP),plasma viscosity and hematocrit were observed following cerebral ischemia-reperfasion injury in rats. Results After the cerebral ischemia-reperfusion injury, regional blood flow in hippocampus was decreased at the 3rd h and 6th h in the right lateral.Level of MAP in the group of ischemia reperfusion for was significant higher than that in the sham operated control group (P 0.01 or P 0.05). Whole blood viscosity in the groups of ischemia reparfusion for 3 h,6 h and 12 h was significantly higher than that in the sham operated coutrol group(P 0.01 or P 0.05). Hematocrit in the groups of ischemia reperfusion for 3 h and 6 h were markedly higher than that in the sham operated coutrol group(P 0.01 or P 0.05). Conclusion Cerebral blood flow is markedly decreased and hemodynamics is affected after focal cerebral infarction in rats.