Impaired Endothelium-dependent Vascular Relaxing Function and Carotid Arterial IMT in The Patients with Hypertension

Objective To impaired endothelium-dependent vasodilatation and arotid arterial IMT in the patients with hypertension. Methods The endothelial dependent vasodilation was measured by high resolution ultrasonograhy,21 patiens with hypertensions and 20 normal controls were studied.Brachial endothelial dependent vasodilation and carotid arterial internal-medial trium(IMT) .Results The Endothelium-dependent vasodilatation was much reduced in patients with essential hypertension compared with that of the control (5.1±6.1)%and(12.3±3.8 )%,P0.01),carotid arterial IMT in patients with essential hypertension was higher than those of the control, but no significant difference between two groups(P0.05) was found. Conclusion Findings support that endothelium-dependent vasodilatation is impaired early in patients with essential hypertension and reflects the atherosclerosis earier than carotid arterial IMT.