Study on attenuation effect of acute renal impairment after reperfusion for hepatic ischemia with propofol

Objective To study the mechanism of acute renal impairment occurred after hepatic ischemia / reperfusion and the protective effect of propofol.Methods Forty male SD rats were randomly divided into sham group;IR2 group(ischemia with reperfusion for2 hr),IR6 group(ischemia with reperfusion for 6 hr);P2 group(propofol for 2h) and P6 group(propofol for 6 hr);and 1 mg/(kg·min)propofol was infused within 30 min before ischemia in P groups,and same volume of sodium lactate Ringer's solution was infused in Sham and IR groups.Blood concentrations of BUN,Cr,TNF-α,SOD,MDA and activities of Na+-K+-ATPase and Ca2+-ATPase were examined at points of 2 and 6 hours after reperfusion.Results Blood concentrations of BUN,Cr,TNF-α and MDA were significantly elevated after reperfusion in IR and P groups.But these figures in P groups were lowered than those of IR groups;levels of SOD and activities of Na+-K+-ATPase and Ca2+-ATPase in P groups were higher than those of IR groups.Conclusion Acute renal impairment followed hepatic ischemia / reperfusion is mainly induced by oxidant stress and neutrophil infiltration in renal tissue.Propofol may have the effect of antioxidation and decreasing infiltration of neutrophils,hence it can attenuate the renal impairment induced by hepatic ischemia / reperfusion.