ScholarLens Back to search
2011•Lishizhen Medicine and Materia Medica ResearchRequires access

Empirical Study of Acupuncture and Moxbustion Pre-disposal on Alzheimer's Disease Rats' axin and β-Catenin's Influence

Feng Shen

Open publisher page 0 citations

Abstract

Objective To discuss the effect of acupuncture and moxbustion pretreatment on GSK-3β PP2A,so to research the mechanism in treating and preventing AD disease. Methods To establish the AD model.All rats were divided into six groups at random: sham group,model group,moxibustion group,electro-acupuncture groups,electro-acupuncture and moxibustion group,ELISA method was used to detect the activity of PP2A and GSK-3β. Results The activity of GSK-3β in model group was increased significantly as compare to normal group(P0.01),but the activity of PP2A was decreased obviously.Electro-acupuncture and moxibustion could adjust those changes. Conclusion The adjusting mechanism of acupuncture to prevent and cure dementia is likely to regulatre the Wnt signal transduction pathways and affect the relevant enzyme expression of learning and memory in hippocampus.

About this research paper

What this paper is about

Objective To discuss the effect of acupuncture and moxbustion pretreatment on GSK-3β PP2A,so to research the mechanism in treating and preventing AD disease. Methods To establish the AD model.All rats were divided into six groups at random: sham group,model group,moxibustion group,electro-acupuncture groups,electro-acupuncture and moxibustion group,ELISA method was used to detect the activity of PP2A and GSK-3β. Results The activity of GSK-3β in model group was increased significantly as compare to normal group(P0.01),but the activity of PP2A was decreased obviously.Electro-acupuncture and moxibustion could adjust those changes. Conclusion The adjusting mechanism of acupuncture to prevent and cure dementia is likely to regulatre the Wnt signal transduction pathways and affect the relevant enzyme expression of learning and memory in hippocampus.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To discuss the effect of acupuncture and moxbustion pretreatment on GSK-3β PP2A,so to research the mechanism in treating and preventing AD disease. Methods To establish the AD model.All rats were divided into six groups at random: sham group,model group,moxibustion group,electro-acupuncture groups,electro-acupuncture and moxibustion group,ELISA method was used to detect the activity of PP2A and GSK-3β. Results The activity of GSK-3β in model group was increased significantly as compare to normal group(P0.01),but the activity of PP2A was decreased obviously.Electro-acupuncture and moxibustion could adjust those changes. Conclusion The adjusting mechanism of acupuncture to prevent and cure dementia is likely to regulatre the Wnt signal transduction pathways and affect the relevant enzyme expression of learning and memory in hippocampus.

Key concepts: Moxibustion, Acupuncture, Medicine, Wnt signaling pathway, Catenin, Disease, Hippocampus, Internal medicine

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Empirical Study of Acupuncture and Moxbustion Pre-disposal on Alzheimer's Disease Rats' axin and β-Catenin's Influence — Research Paper | ScholarLens