Ten-year follow-up of fifty patients with HBsAg-negative chronic hepatitis B

Objective To investigate the clinical outcomes and prognosis on patients with HBsAg-negative chronic hepatitis B.Methods 50 patients with HBsAg-negative chronic hepatitis B were enrolled in this study.Changes of the serum markers of hepatitis B,the level of HBV DNA,liver function and color Doppler ultrasongraphy from these patients were analyzed comparatively with retrospective review before and after ten years.Results All these patients were survived after 10 years.The serum levels of ALT rising(ALT100IU/ml)were observed for only 6 of 50 cases,the reasons three for fatty liver disease,three for drugs resulting in the liver injuries,and the levels of ALT recovered when drugs stopped.The rest patients of liver function was normal generally.HBV DNA levels were quantified,1 case for 1.4E+03 copies/ml and 49 cases far below the detectable limit.According to the ultrasongraphy,10 cases were diagnosed as chronic hepatitis,3 for fatty liver diease and 1for liver cirrhosis,hepata carcinoma was not detected.Conclusion The changes of clinical symptoms and liver function were stable relatively on patients with HBsAg-negative chronic hepatitis B and the disease advanced slowly.They had good clinical outcomes and prognosis after 10 years.