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2010•Acta Academiae Medicinae Qingdao UniversitatisRequires access

EXPRESSIONS OF MATRIX METALLOPROTEINASE-10,METALLOPROTEINASE-11 AND TISSUE INHIBITOR OF METALLOPROTEINASE-2 IN GASTRIC CARCINOMA

Hongyu Zhang

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Abstract

Objective To study the expressions of matrix metalloproteinase-10 (MMP-10), metalloproteinase 11 (MMP-11) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in gastric carcinoma and explore the mechanism of invasion and metastasis of the cancer.MethodsExpressions of MMP-10, MMP-11 and TIMP-2 were studied via immunohistochemistry in specimens resected from 45 patients with gastric carcinoma and 20 paraneoplastic normal mucosa (PNM).ResultsDifferences in expressions of MMP-10, MMP-11 and TIMP-2 were significant between cancer mucosa and PNM (χ2=4.30-6.37,P0.05). Expressions of MMP-10 and MMP-11 were both correlated with tumor size, depth of tumor invasion, LN metastasis and TNM stage (χ2=6.46-15.91;P0.05,0.01); expression of TIMP-2 was correlated with LN metastasis (χ2=4.91,P0.05), and that of MMP-10 and MMP-11 were positively correlated with that of TIMP-2 (γ=0.29,0.34;P0.05).ConclusionThe abnormal expressions of MMP-10, MMP-11 and TIMP-2 are closely related with the metastasis and that can be used as important parameters for the judgement of biological behaviour and prognosis of gastric carcinoma.

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Objective To study the expressions of matrix metalloproteinase-10 (MMP-10), metalloproteinase 11 (MMP-11) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in gastric carcinoma and explore the mechanism of invasion and metastasis of the cancer.MethodsExpressions of MMP-10, MMP-11 and TIMP-2 were studied via immunohistochemistry in specimens resected from 45 patients with gastric carcinoma and 20 paraneoplastic normal mucosa (PNM).ResultsDifferences in expressions of MMP-10, MMP-11 and TIMP-2 were significant between cancer mucosa and PNM (χ2=4.30-6.37,P0.05). Expressions of MMP-10 and MMP-11 were both correlated with tumor size, depth of tumor invasion, LN metastasis and TNM stage (χ2=6.46-15.91;P0.05,0.01); expression of TIMP-2 was correlated with LN metastasis (χ2=4.91,P0.05), and that of MMP-10 and MMP-11 were positively correlated with that of TIMP-2 (γ=0.29,0.34;P0.05).ConclusionThe abnormal expressions of MMP-10, MMP-11 and TIMP-2 are closely related with the metastasis and that can be used as important parameters for the judgement of biological behaviour and prognosis of gastric carcinoma.

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Available abstract

Objective To study the expressions of matrix metalloproteinase-10 (MMP-10), metalloproteinase 11 (MMP-11) and tissue inhibitor of metalloproteinase-2 (TIMP-2) in gastric carcinoma and explore the mechanism of invasion and metastasis of the cancer.MethodsExpressions of MMP-10, MMP-11 and TIMP-2 were studied via immunohistochemistry in specimens resected from 45 patients with gastric carcinoma and 20 paraneoplastic normal mucosa (PNM).ResultsDifferences in expressions of MMP-10, MMP-11 and TIMP-2 were significant between cancer mucosa and PNM (χ2=4.30-6.37,P0.05). Expressions of MMP-10 and MMP-11 were both correlated with tumor size, depth of tumor invasion, LN metastasis and TNM stage (χ2=6.46-15.91;P0.05,0.01); expression of TIMP-2 was correlated with LN metastasis (χ2=4.91,P0.05), and that of MMP-10 and MMP-11 were positively correlated with that of TIMP-2 (γ=0.29,0.34;P0.05).ConclusionThe abnormal expressions of MMP-10, MMP-11 and TIMP-2 are closely related with the metastasis and that can be used as important parameters for the judgement of biological behaviour and prognosis of gastric carcinoma.

Key concepts: Matrix metalloproteinase, Tissue inhibitor of metalloproteinase, Metalloproteinase, Metastasis, Immunohistochemistry, Cancer, Pathology, Matrix metalloproteinase 9

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EXPRESSIONS OF MATRIX METALLOPROTEINASE-10,METALLOPROTEINASE-11 AND TISSUE INHIBITOR OF METALLOPROTEINASE-2 IN GASTRIC CARCINOMA — Research Paper | ScholarLens