Effects of herbal retention-enema and cisapride on anal kinetics in patients with slow transit constipation of deficiency syndrome

Objective To observe the effects of herbal retention-enema and cisapride on anal kinetics in patients with slow transit constipation.Methods Sixty subjects were randomized into two groups: treatment group in which 30 cases were treated with Supplementing Qi and activating blood circulation bowel enema retention enema combined with oral administration of cisapride,The control group of 30 cases was taking cisapride;Two groups were treated for 14 days,through the observation of the two groups before and after treatment of anal dynamics change,objective evaluation of Yiqi Huoxue bowel enema in the treatment of slow transit constipation of deficiency syndrome of effectiveness,safety.Results ①Colonic transit test positivity rate,number of markers and elimination rate of discharge:The two groups before and after treatment there was a significant difference in(P0.01);After treatment in two groups have no significant difference in efficiency comparison(P0.05);But the treatment group in 2 weeks after the results were better than the control group.②Anorectal manometry: Rectal sensory thresholds,initial bowel sensation threshold and the maximum tolerance,maximal anal systolic blood pressure and diastolic blood pressure and other indicators of anal canal,The initial feeling of rectum in the treatment group with significant difference before and after treatment(P0.01);While the control group showed no significant difference before and after treatment(P0.05);After two weeks,the treatment group was better than the control group the indexes.The treatment group,control group total effectiveness respectively is 83.3%,80%;Comparison of clinical efficacy between groups,the difference was not statistically significant.The two groups before treatment of colonic transit test positivity rate,discharge and the number of markers exclusion rate had no statistical significance(P0.05).The two groups before and after treatment group,the index difference has statistics significance(P0.05).Between group after treatment,there were no significant differences among the various indicators(P0.05).Between group discontinued 14 days more,the index difference has statistics significance(P0.05)(table 2).The two groups before treatment of anorectal manometry showed no significant difference(P0.05).Before and after treatment group,treatment group rectal sensory thresholds,initial rectal sensory thresholds,defecation rectal MTD,anal diastolic pressure difference has statistics significance(P0.01),The control group had no statistical significance between each index(P0.05).Between group discontinued 14 days more,the index difference has statistics significance(P0.05)(table3).Conclusion Benefiting qi for activating blood circulation and bowel enema combined with western medicine on patients with slow transit constipation anal dynamics have obvious effects on,and also can improve the curative effect in the near future,but traditional Chinese medicine retention enema anal systolic blood pressure and diastolic blood pressure effect and mechanism need further study.