Significance of MCV,MCH Joint Hb Electrophoresis in the Mediterranean Anemia Intervention

Objective: To study the value of the commonly used thalassemia screening methods in the intervention of thalassemia,including the red cell mean corpuscular volume( MCV),mean corpuscular hemoglobin( MCH),hemoglobin( Hb) electrophoresis. Methods: MCV and MCH were used for phenotypes thalassemia screening of 5000 cases of participants,and Hb electrophoresis was used for those who were detected with MCV and MCH decrease( MCV 80 fl,MCH 27 pg). Genetic diagnosis would be used if the result of Hb electrophoresis was abnormal. Results: MCV and MCH of609 cases were detected decreased,accounting for 12. 18% of all 5 000 participants. Hb electrophoresis of 460 cases were abnormal and were suspicious of thalassemia,accounting for 9. 2% of all participants,and 285 cases were confirmed by genetic diagnosis. Among the 285 cases,168 cases of α-thalassemia were confirmed,114 cases were diagnosed with β-thalassemia,and 3 cases were diagnosed with both. Conclusion: Methods of MCV,MCH and Hb electrophoresis are easy to operate,with high sensitivity,specificity and low cost,which make them easily accepted by the public,and they are quite suitable for primary hospitals.