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2002•Journal of environmental healthRequires access

Micronuclei Induced by Sulfur Dioxide Inhalation in Bone Marrow Cells of Mice

Ziqiang Meng

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Abstract

Objective To investigate the genetic toxicological effects of sulfur dioxide (SO2), a pollutant in air. Methods The inductive effects of SO2 inhalation on micronuclei formation in the polychromatophilic erythroblasts (PCE) of mouse bone marrow were studied. Results (1) SO2 inhalation caused a significant increase of both the frequency of micronuclei in PCE cells and the frequency of PCE cells with micronuclei; (2) In the PCE cells, both the frequency of cells with mono-micronuclei and the frequency of cells with bi-micronuclei were significantly increased as concentrations of SO2 increasing. Conclusion With the increase of concentrations of SO2, the damage of cytogenetic material became more serious and revealed a more clear dose-effect relationship. It suggested that SO2 was a clastogen and genotoxic agent.

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What this paper is about

Objective To investigate the genetic toxicological effects of sulfur dioxide (SO2), a pollutant in air. Methods The inductive effects of SO2 inhalation on micronuclei formation in the polychromatophilic erythroblasts (PCE) of mouse bone marrow were studied. Results (1) SO2 inhalation caused a significant increase of both the frequency of micronuclei in PCE cells and the frequency of PCE cells with micronuclei; (2) In the PCE cells, both the frequency of cells with mono-micronuclei and the frequency of cells with bi-micronuclei were significantly increased as concentrations of SO2 increasing. Conclusion With the increase of concentrations of SO2, the damage of cytogenetic material became more serious and revealed a more clear dose-effect relationship. It suggested that SO2 was a clastogen and genotoxic agent.

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Available abstract

Objective To investigate the genetic toxicological effects of sulfur dioxide (SO2), a pollutant in air. Methods The inductive effects of SO2 inhalation on micronuclei formation in the polychromatophilic erythroblasts (PCE) of mouse bone marrow were studied. Results (1) SO2 inhalation caused a significant increase of both the frequency of micronuclei in PCE cells and the frequency of PCE cells with micronuclei; (2) In the PCE cells, both the frequency of cells with mono-micronuclei and the frequency of cells with bi-micronuclei were significantly increased as concentrations of SO2 increasing. Conclusion With the increase of concentrations of SO2, the damage of cytogenetic material became more serious and revealed a more clear dose-effect relationship. It suggested that SO2 was a clastogen and genotoxic agent.

Key concepts: Micronucleus test, Clastogen, Micronucleus, Bone marrow, Inhalation, Sulfur dioxide, Chemistry, Toxicology

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