2014•China Modern MedicineRequires access
Comparative study of post-effect of fleroxacin and lomefloxacin
LI Quan-gu
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Abstract
Objective To study the safety of fluoroquinolone antibiotics and compare post-effect of fleroxacin and lomefloxacin. Methods Post-effect of fleroxacin and lomefloxacin in inhibiting Gram-negative and Gram-positive bacteria were measured by optical density method. Results With increasing of concentration of fleroxacin and lomefloxacin, PAE was increased gradually and proportional to density and there was a statistical difference of different concentration in different groups(P0.05).When the concentration was 4 MIC and 8 MIC,PAE value was obviously higher than the other concentration;for the same density,PAE value of fleroxacin were all higher than lomefloxacin(P0.05). Conclusion Post-effect of fleroxacin and lomefloxacin are significant and the former is superior to the later,and this should be based on to design dosage regimen.