Comprison of Oxymatrine and Aciclovir in the Treatment of Chronic Hepatitis B.

Objective To survey the clinical therapeutic effectiveness of oxymatrine in the treatment of chronic hepatitis B.Methods 83 patients with chronic hepatitis B were randomly divided into two groups.42 patients in the treatment group were given eath 600mg of oxymatrine im,qd,for 3 month;41 patients in the control group were given each 100mg of aciclovir,per day in 5 divided doses po for 2 month.In the meantime,patients of both groups were subjectal to coventional treatment with hepatinica.Changes in clinical symptoms and signs,liver function tests as well as serological markers of HBVM were compared. Results The improv rate of clinical symptom and lirer function in the treatment were higher than that of coutrol group( P 0.05),HBeAg turned to negative in 50.0% of treatment group compared 21.9% in control group,HBV-DNA turned to negative on 52.4% and 24.4% in the two groups,side effects had not been found. Conclusion Oxymatrine is an effeclive drug in treating chronic hepatitis B,It can be recommended for a wider clinical use.