2012•Wuhan Daxue xuebao. Yixue banRequires access
Effects of Valproate on Methamphetamine and Cocaine Behavioral Sensitization of Mice
Ke Jin
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Abstract
Objective: To explore the effects of valproate on methamphetamine and cocaine behavioral sensitization of mice.Methods: The locomotor activity was measured in the animal model of methamphetamine and cocaine behavioral sensitization.The relative experiments were carried out as below: the influence of methamphetamine and cocaine on behavioral sensitization,the influence of single or multiple injections of valproate on methamphetamine and cocaine induced high-activity,and the influence of valproate on the behavioral sensitization of methamphetamine and cocaine induced high-activity.Results: ①Both methamphetamine and cocaine can enhance the locomotor activity,and the effect increased in pace with the administration numbers;②valproate had no effect on the high activity resulted by acute methamphetamine and cocaine;③The locomotor activities in an hour after the treatment of methamphetamine or cocaine were(15 642.7±286.4) and(14 358.9±273.6) separately,while valproate only inhibited the formation of the behavioral sensitization caused by methamphetamine.Conclusion: Methamphetamine and cocaine have different neural mechanism in the formation process of the behavioral sensitization.The tiny difference of these two psychostimulant maybe has a certain clinical significance.