Clinical Significance of CA242 and CA19-9 in Colorectal Cancer

Objective:To investigate the clinical value of CA242 and CA19-9(tumor marker) in the diagnosis,treatment and prognosis of colorectal cancer. Methods: Serum levels of CA242 andCA19-9 in 35 cases with colorectal cancer and 204 cases without cancer were examined by enzyme linked immunosorbent assay (ELISA) . Results: Serum levels of CA242 and CA19-9 were significantly higher in the patients with colorectal cancer than that without (99.51±112.41U/mL vs 9.63± 15.50U/mL and 46.23±70.82U/ mL vs 8.42 ± 22.02U/mL) , respectively(P 0.01) . The diagnostic sensitivity,specificity and accuracy of serum CA242 and CA19-9 were 60%, 96.57% and 91.21% vs 31.43%,95.59% and 86.19% .respectively. CA242 was more sensitive than CA19-9 in the diagnosis of colorectal cancer, but the difference in specificity and accuracy was not marked. The sensitivity of examination of CA242 and CA19-9 jointly was higher than singly (68.57% vs 31.43%). The sensitivity of CA242 and CA19-9 was higher in the diagnosis of colon cancer (64.71% and 41. 18%)than rectal cancer (55.55%and 22.22%). For the patients accompanied by serum CA242 level elevated or not , the therapeutic responses were 14.29% and 57.14% respectively ( P 0.05),and the median survival was 6.5 months and 9 months. For the patients accompanied by serum CA19-9 level elevated or not, the therapeutic responses were 27.27% and 33.33% respectively (P 0.05), and the median survival was 6.5 months and 7 months. Conclusion: CA242 and CA19-9 are useful serum tumor markers for the diagnosis of colorectal cancer. Examination of serum CA242 and CA19-9 jointly helps improve the diagnostic sensitivity, evaluate therapeutic effects and prognosis, and follow the patient' s condition of colorectal