Bone Morphogenetic Protein 4,Bone Morphogenetic Protein 7 and Polycystic Ovary Syndrome

Polycystic ovary syndrome(PCOS) is one of the common endocrine disorder affecting women of reproductive age,and is characterized by oligo- or anovulation,hyperandrogenism and polycystic ovaries. Some findings show that the cause of PCOS has something to do with the abnormal regulation of transcription factors,such as the Transforming Growth Factor-beta(TGF-β) superfamily. Bone Morphogenetic Protein 4(BMP4) and Bone Morphogenetic Protein 7(BMP7) are both important members in TGF-β superfamily,and play an significant role in the folliculogenesis、ovulation and the development and apotosis of granulosa cells in ovary. As a result,in order to know more about the pathogenesis and treatment of PCOS,it is necessary to make clear the regulation function of BMP4 and BMP7 in female reproductive system.