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Biological Properties,Cultivation and Identification of Neural Stem Cells

Lili Ji

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Abstract

Neural stem cells (NSCs) that reside in different regions of central nervous system (CNS) of embryo, fetus and adult, can proliferate and be differentiated into neurons and neuroglia. NSCs can be isolated from the subventricular zone, dentate gyrus, striatum, subependymal region and cultured in vitro when the concentrations of EGF and bFGF in the medium are 20 ng·mL-1 equally. NSCs will differentiate into neurons and glial cells if the concentration of bFGF is 1~10 ng·mL-1 . Many ways have been used to identify NSCs in experiments. Expressing nestin, self duplication and multipotential differentiation are three conditions for identifying NSCs.

About this research paper

What this paper is about

Neural stem cells (NSCs) that reside in different regions of central nervous system (CNS) of embryo, fetus and adult, can proliferate and be differentiated into neurons and neuroglia. NSCs can be isolated from the subventricular zone, dentate gyrus, striatum, subependymal region and cultured in vitro when the concentrations of EGF and bFGF in the medium are 20 ng·mL-1 equally. NSCs will differentiate into neurons and glial cells if the concentration of bFGF is 1~10 ng·mL-1 . Many ways have been used to identify NSCs in experiments. Expressing nestin, self duplication and multipotential differentiation are three conditions for identifying NSCs.

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Available abstract

Neural stem cells (NSCs) that reside in different regions of central nervous system (CNS) of embryo, fetus and adult, can proliferate and be differentiated into neurons and neuroglia. NSCs can be isolated from the subventricular zone, dentate gyrus, striatum, subependymal region and cultured in vitro when the concentrations of EGF and bFGF in the medium are 20 ng·mL-1 equally. NSCs will differentiate into neurons and glial cells if the concentration of bFGF is 1~10 ng·mL-1 . Many ways have been used to identify NSCs in experiments. Expressing nestin, self duplication and multipotential differentiation are three conditions for identifying NSCs.

Key concepts: Neural stem cell, Subependymal zone, Subventricular zone, Nestin, Biology, Dentate gyrus, Neurosphere, Neuroscience

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