Antioxidation effect of banana peel polysaccharides on oxidative injury in mice

Objective To study the antioxidation of banana peel polysaccharides on D-galactose induced oxidative injury in mice.Methods Mice in treatment groups were orally given banana peel polysaccharides at the dose of 50,100,200 mg/(kg·bw) respectively.The spleen and thymus gland were separated after 42 days of the treatment to determine their indices.In addition,the malondialdehyde(MDA) contents,superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) activities in serum and liver were assayed.Results In the dose groups of 100,200 mg/(kg·bw),body weight gain were 5.93±0.68,6.10±0.23,the thymus index were 4.38±0.07,4.86±0.17 and the spleen index were 2.55±0.13,3.09±0.21 with significant increases(P0.01).The content of MDA significantly decreased and the activtiy of SOD and GSH-Px significantly increased both in serum and liver of mice with oxidative injury(P0.01).Conclusion The banana peel polysaccharides have significant antioxidation effect on D-galactose induced oxidative injury in mice.