1999•Unpublished venueRequires access

The distribution of three α1-adrenoceptor subtypes in different components of rat heart

Sun Xiao

Abstract

The distribution of three subtypes ofα_1-adrenoceptor in ventricle and atrium of rats was investigated. Methods: Radioligand binding assay was performed. Results: The contents of α_1-adrenoceptor were (81±13) fmol/mg, (86 ± 15) fmol/mg protein in ventricle and left atrium from Wistar rats, respectively. The ratios of subtype α_1A-, α_1B- and α_1D-adrenoceptor in ventricle or atrium were 25 %, 45 % and 30%, respectively. Conclusion: The density of total α_1-adrenoceptor and its three subtypes in atrium were comparable with those in ventricle of rats.

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Key concepts: Ventricle, Atrium (architecture), Left atrium, Internal medicine, Radioligand, Right atrium, Endocrinology, Distribution (mathematics)