Toxicologic Study on Jingfukang Granules

Objective: To observe the acute toxicity of Jingfukang(JFK) in mice and its long-period toxicity in rats. Methods: The maximal tolerance dose was tested by gastric infusion of two times oral dose of JFK. Three groups of rats (in high,medium and low dosage of JFK) were administered with repeated gastric infusion of JFK for 180 days. Body weight, hema-tological and hematobiochemical parameters, coefficient and histomorphological figure of organs (the heart, liver, spleen, Lungs, kidneys, adrenals, testes, prostate, pancreas uterus, brain, thymus) were examined in 90 days, 180 days and 30 days after the cessation of JFK. Results: The oral maximal tolerance of JFK in mice was more than 220.80 (crude drugs) g/kg (equal to 194 times of clinical dose). In the long-period toxicity test, after adminisered repeatedly for 90 days the grea and the coefficient of livers and kidneys were increased in high-dosage group. After administered repeatedly for 180 days, the grea increased in high-dosage group and the coefficient of liver increased in high, medium and low-dosage. Kidneys of one rat occurred the following pathological changes: the epithelial cell of proximal convoluted tubules swelling. The changes of hematobiochemical, pathological and coefficient of organs could completely recover in 30 days after stopping the drug. Conclusion: JFK administration by long-period might slightly injure the renal function of rats, but the injury was reversible. It is safe to administer the prescribed dose of JFK.