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2011•Chinese Journal of Laboratory DiagnosisRequires access

Serum IL-23 and IL-10 assay in patients with colorectal carcinoma and significance in tumor progression

Yingyin Zhang

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Abstract

Objective The aim of the study was to determine whether IL-23,IL-17,IL-10,and IFN-α levels are involved in the development and progression of colorectal carcinoma in humans.Methods A group of 50 patients and 20 healthy volunteers were included in the study.The quantitative determination of IL-23,IL-17,IL-10,and IFN-α serum levels were performed by ELISA.Results We observed significantly enhanced IL-23 and IL-10 in colorectal carcinoma patients compared to the controls.The highest level of IL-10 was detected in patients with stage IV,which was significantly greater than those in stages I,II,and III.Conclusion We found that IL-23 and IL-10 levels were significantly elevated in patients'sera,in contrast to IL-17 and IFN-α and this serum cytokine profile may play a role in tumor development.In addition,an increased level of IL-10 was strongly associated with the progression of colorectal carcinoma.

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Objective The aim of the study was to determine whether IL-23,IL-17,IL-10,and IFN-α levels are involved in the development and progression of colorectal carcinoma in humans.Methods A group of 50 patients and 20 healthy volunteers were included in the study.The quantitative determination of IL-23,IL-17,IL-10,and IFN-α serum levels were performed by ELISA.Results We observed significantly enhanced IL-23 and IL-10 in colorectal carcinoma patients compared to the controls.The highest level of IL-10 was detected in patients with stage IV,which was significantly greater than those in stages I,II,and III.Conclusion We found that IL-23 and IL-10 levels were significantly elevated in patients'sera,in contrast to IL-17 and IFN-α and this serum cytokine profile may play a role in tumor development.In addition,an increased level of IL-10 was strongly associated with the progression of colorectal carcinoma.

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Available abstract

Objective The aim of the study was to determine whether IL-23,IL-17,IL-10,and IFN-α levels are involved in the development and progression of colorectal carcinoma in humans.Methods A group of 50 patients and 20 healthy volunteers were included in the study.The quantitative determination of IL-23,IL-17,IL-10,and IFN-α serum levels were performed by ELISA.Results We observed significantly enhanced IL-23 and IL-10 in colorectal carcinoma patients compared to the controls.The highest level of IL-10 was detected in patients with stage IV,which was significantly greater than those in stages I,II,and III.Conclusion We found that IL-23 and IL-10 levels were significantly elevated in patients'sera,in contrast to IL-17 and IFN-α and this serum cytokine profile may play a role in tumor development.In addition,an increased level of IL-10 was strongly associated with the progression of colorectal carcinoma.

Key concepts: Medicine, Colorectal cancer, Internal medicine, Interleukin 10, Cytokine, Carcinoma, Tumor progression, Stage (stratigraphy)

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Serum IL-23 and IL-10 assay in patients with colorectal carcinoma and significance in tumor progression — Research Paper | ScholarLens