Preparation and Bioavailability of Ibuprofen Suspension

Ibuprofen suspension was prepared with CMC-Na, sucrose and mannitol as excipients. The pharmacokinetics and bioavailability of ibuprofen suspension in 10 healthy volunteers were compared with ibuprofen tablets. The concentration of ibuprofen in serum was determined by HPLC. The major pharmacokinetics parameters of ibuprofen suspension and tablets were t max (0.790±0.360) h and ( 4.024 ±0.819) h, c max (22.28±3.68) μg/ml and (20.04±3.370) μg/ml, t 1/2 (2.020±0.270) h and ( 2.026 ± 0.265 ) h, respectively. The relative bioavailability of ibuprofen suspension was (91.46±10.59)%.