Intermediate clinical outcome in acute myocardial infarction patients after intensive atorvastatin treatment before emergency PCI

Objective To observe the intermediate clinical outcome in patients with STEMI who received intensive atorvastatin treatment before emergency PCI.Methods STEMI patients undergoing emergency PCI were randomly divided into group A(n= 32),group B(n= 32)and group C (n= 38).Patients in group A received 80 mg atorvastatin daily before PCI followed by 40 mg atorvastatin daily for 1 month and a maintenance dose of 20 mg atorvastati daily thereafter.Patients in group B were given 40 mg atorvastatin daily for 1 month after PCI and a maintenance dose of 20 mg atorvastatin daily thereafter.Patients in group C administered 20 mg atorvastatin daily after PCI.STR were evaluated at 90 min after PCI,hs-CRP were assayed 24 h and 72 h after PCI.Peak CK and CK-MB levels were measured and MACE were recorded 6 months after PCI.Results No significant difference was found in hs-CRP level among the 3 groups at admission and 24 h after PCI(F0.05).The hs-CRP level was significantly higher in groups B and C than in group A at 72 h after PCI(P0.05)while no significant difference was observed in hs-CRP level between groups B and C.No significant difference was found in CK and CK-MB level among the 3 groups before PCI.The peak CK and CK-MB levels were significantly higher while the average value and incidence of STR were significantly lower in groups B and C than in group A(P0.05).The incidence of MACE was 9.4%,9.4%and 10.5%respectively in 3 groups(P0.05).Conclusion Intensive atorvastatin treatment of STEMI patients before emergency PCI can inhibit inflammatory reactions and alleviate myocardial infarction.