Stress response and hemodynamic change during laparoscopic cholecystectomy under general anesthesia and general-epidural combined anesthesia

Objectives:To observe the stress response and hemodynamic change during laparoscopic cholecystectomy(LC) under general anesthesia and general-epidural combined anesthesia.Methods:28 patients of LC were divided into general anesthesia group(G group n=14) and general-epidural anesthesia group(GE group n=14) randomly.The HR、SBP、MAP,plasma concentration of epinephrine(E),norepinepherine(NE),blood glucose、cortisol,PaCO2 and pH were measured before and after peritoneal insufflation of CO2.Results:The HR,SBP and MAP were increased significantly in group G than those in group GE(P0.05).The concentrations of E,NE and blood glucose were increased significantly after peritoneal insufflation of CO2 in group G,while there were no changes in group GE.The concentration of cortisol was increased significantly in both groups.The increasing of PaCO2 and decreasing of pH were all appeared after peritoneal insufflation of CO2.Conclusions:The stress response and hemodynamic changes were slighter during LC under general-epidural anesthesia than general anesthesia.