Different plasma concentrations of remifentanil combined with sevoflurane used to tracheal intubation in pediatric patients

Objective To observe the tracheal intubation conditions and hemodynamic changes during remifentanil target controlled infusion(TCI)at different plasma concentrations combined with 2.5%sevoflurane.Methods Sixty pediatric patients were randomly allocated into three groups,remifentanil were given using TCI at plasma concentration of 2 ng/ml(group1),3 ng/ml(group 2),4 ng/ml(group3)in each group respectively.Anesthsia was induced by sevoflurane inhalation at 8%,when the patients lost consciousness,maintained by 2.5%sevoflurane inhalation for 5 mins,anesthesia were followed by remifentanil TCI.MAP and HR were recorded before induction,before intubation,and at 1 and 3 min after intubation,intubation conditions were evaluated.Results The satisfactory degree of intubation conditions in group 1 was significantly lower compared to that in group 2 and 3,but there was no significantly different between group 2 and 3.There was a significant reduction in MAP and HR before intubation compared to those before induction in all groups.Tracheal intubation was associated with an increase in group 1 than that in group 2 and 3.There was no significant difference in MAP and HR at 1 and 3 min after intubation in group 2 and 3.Conclusion Remifentanil TCI with 3 ng/ml combined with 2.5%sevoflurane without relaxants can provided clinically acceptable tracheal intubation conditions and stable hemodynamic.