Effect of Curcumine on serum ICAM-1 level and prognosis of septic rats

Objective To investigate the effect of curcumine(Cur) on septic rats and its possible mechanisms. Methods 120 SD rats (specific pathogen free) were randomly divided into sham operation group (Sham group),cecal ligation and puncture (CLP) group (CLP group)and Cur treating group( Cur group). Groups of 5 animals were sacrificed at 0,3,6,12,24 and 48 hours after operation. The remaining animals were observed for survival time after CLP in 96 hours.Blood samples were harvested before animals died. Before sacrifice,the septic severity score were recorded.After sacrifice,the levels of intercellular adhesion molecule-1 (ICAM-1) in plasma were determined. Rusults The degree of severity of sepsis was higher in CLP group than those of other groups; The degree of Cur groups was lower than that of CLP group,but was higher than that of Sham group (both P0.01). The survival time of septic rats was shorter in CLP group than those in other groups; The survival time in Cur group was shorter than that of Sham group,but was longer than that of CLP group(both P0.01). The levels of ICAM-1 in plasma rose to the peak at 24 hours after CLP in CLP and Cur groups,but the value in Cur group was significantly lower than that of CLP group at all time points (all P0.01). Conclusion Curreduces the severity of septic rats and prolongs the survival time, probably associated with inhibition of ICAM-1 expression.