2008•Chinese journal of integrated traditional and Western medicineRequires access

The study of ribonucleic acid inducing the apoptosis of hepatoma cell strain-HEPG2

Xu Dong

Abstract

Objective:To study the effect of ribonucleic acid inducing the apoptosis on hepatoma cell strain-HEPG2.Methods:The hepatoma cell strain-HEPG2 were divided into three groups,control group,camptothecine(CPT) group and ribonucleic acid group.The ribonucleic acid group was divided into dosage effect group and time effect group.The quantition detection of the apoptosis of hepatoma cell strain-HEPG2 was observed with flow cytometer.Results:With the cell cultivation time lasting,the apoptosis of hepatoma cell strain-HEPG2 in ribonucleic acid group was incresing gradually.The apoptosis rate 38.6% was the highest in 20h after inducing by ribonucleic acid.The best concentration was 20μl/ml for HEPG2.Conclusion:The ribonucleic acid has an effect of promoting the apoptosis of HEPG2,and has a time and concentration dependence.

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Key concepts: Apoptosis, Strain (injury), Cell, RNA, Chemistry, Molecular biology, Biochemistry, Biology