Simultaneous determination of menthol,borneol,patchoulic alcohol and muscone in Compound Shexiang Injection by GC

AIM:To establish the simultaneous determination of menthol, borneol, patchoulic alcohol and muscone in Compound Shexiang Injection (Moschus, Herba Pogostemonis, Borneolum Syntheticum, Mentholum, etc) by GC. METHODS: The GC system consisted of capillary column, Rtx-Wax-30 M; FID as the detector. The programmed temperature-GC and internal standard method were employed to determine four kinds of components in Compound Shexiang Injection. RESULTS: Menthol, borneol, patchoulic alcohol and muscone in Compound Shexiang Injection and n-octadecane have been separated well under the same chromatographic condition. The average recoveries of menthol, borneol, patchoulic alcohol and muscone were 99.76% (RSD=1.48%), 99.36%(RSD=1.99%), 99.15%(RSD=1.67%), 98.87%(RSD=1.57%), respectively. CONCLUSION: The method is sensitive, accurate, separable and reproducible, and can be used to control the quality of Compound Shexiang Injection.