ScholarLens Back to search
2002•Unpublished venueRequires access

The Effect of Tumor Necrosis Factor and Endotoxin in Severe Acute Pancreatitis

Ping Zhang

Open publisher page 0 citations

Abstract

Objective:To investigate the effect of tumor necrosis factor-α(TNF α) and endotoxin in the acute severe pancreatitis.Method:After SAP model induced in dogs,plasma levels of TNF α?endotoxin and amylase were measured at 6h?12h?24h?48h?after operation.Pathological changes and ultrastructure of pacreatitis were observed.Results:The plasm levels of TNF α?endotoxin and amylase were significantly higher in SAP group than in the control group,especially on 12h?24h?(P0.01～P0.05).The tissue demages of pancreas were observed.The pancreatic cells observed by microscope were demaged.There were hemorrhagic necrosis.Part of nucleus were karyolysis.There were much leukocyts around the necrosis tissue of pancreas.Conclusion:The TNF α and endotoxin were important factors in the development of severe acute pancreaetitis.The development of severe acute pancreaetitis may be alleviated by inhibitng the production of TNF α and endotoxin.

About this research paper

What this paper is about

Objective:To investigate the effect of tumor necrosis factor-α(TNF α) and endotoxin in the acute severe pancreatitis.Method:After SAP model induced in dogs,plasma levels of TNF α?endotoxin and amylase were measured at 6h?12h?24h?48h?after operation.Pathological changes and ultrastructure of pacreatitis were observed.Results:The plasm levels of TNF α?endotoxin and amylase were significantly higher in SAP group than in the control group,especially on 12h?24h?(P0.01～P0.05).The tissue demages of pancreas were observed.The pancreatic cells observed by microscope were demaged.There were hemorrhagic necrosis.Part of nucleus were karyolysis.There were much leukocyts around the necrosis tissue of pancreas.Conclusion:The TNF α and endotoxin were important factors in the development of severe acute pancreaetitis.The development of severe acute pancreaetitis may be alleviated by inhibitng the production of TNF α and endotoxin.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective:To investigate the effect of tumor necrosis factor-α(TNF α) and endotoxin in the acute severe pancreatitis.Method:After SAP model induced in dogs,plasma levels of TNF α?endotoxin and amylase were measured at 6h?12h?24h?48h?after operation.Pathological changes and ultrastructure of pacreatitis were observed.Results:The plasm levels of TNF α?endotoxin and amylase were significantly higher in SAP group than in the control group,especially on 12h?24h?(P0.01～P0.05).The tissue demages of pancreas were observed.The pancreatic cells observed by microscope were demaged.There were hemorrhagic necrosis.Part of nucleus were karyolysis.There were much leukocyts around the necrosis tissue of pancreas.Conclusion:The TNF α and endotoxin were important factors in the development of severe acute pancreaetitis.The development of severe acute pancreaetitis may be alleviated by inhibitng the production of TNF α and endotoxin.

Key concepts: Acute pancreatitis, Medicine, Tumor necrosis factor alpha, Necrosis, Pancreas, Pathological, Tumor necrosis factor α, Pancreatitis

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Effect of Tumor Necrosis Factor and Endotoxin in Severe Acute Pancreatitis — Research Paper | ScholarLens