2009•Zhongguo yaolixue tongbaoRequires access

Research of enalapril on rat myocardial fibrosis and its mechanism

Shijie Yang

Abstract

Aim To investigate the effects of enalapril(Ena) on cardiac fibrosis induced by isoprenaline(Iso) and to explore its mechanism.Methods Effect of Ena and captopril(Cap) on collagen content,HW/BW,LVI,hydroxyprolnie(Hyp) level,and TGF-β1 protein expression was observed with IH and WB in rats induced by Iso subcutaneous injection.Results Different doses of Ena could decrease HW/BW,LVI and Hyp level dramatically,and decrease TGF-β1 protein expression which was closely related to myocardial fibrosis(MF).Conclusion Enalapril can inhibit TGF-β1 protein expression,by which inhibit myocardial fibrosis.

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Key concepts: Isoprenaline, Enalapril, Captopril, Myocardial fibrosis, Fibrosis, Protein expression, Internal medicine, Subcutaneous injection