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2009•Guangxi Medical JournalRequires access

Expression and relativity of CerbB-2,COX-2 in nasopharyngeal carcinoma

Xiangping Wang

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Abstract

Objective To evaluate the relationship between the expression of CerbB-2 and COX-2 in nasopharyngeal carcinoma,and examine their possible effects on pathogenesis and progression of nasopharyngeal carcinoma.Methods The expression of CerbB-2 and COX-2 in 90 nasopharyngeal carcinoma tissues and 22 nasopharyngitis tissues was detected by SP immunohistochemical method.Results The positive expression rate of CerbB-2 and COX-2 protein in nasopharyngeal carcinoma tissues were 65.56% and 67.78%,respectively,and those in nasopharyngitis tissues were 31.82% and 36.36%,respectively,the difference was significant(P0.05).There was positivel correlation between the expression of CerbB-2 and COX-2 in nasopharyngeal carcinoma(r=0.526,P0.05).Conclusion These results demonstrated high expression of CerbB-2 and COX-2 may involve in the pathogenesis and progression of nasopharyngeal carcinoma.

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Objective To evaluate the relationship between the expression of CerbB-2 and COX-2 in nasopharyngeal carcinoma,and examine their possible effects on pathogenesis and progression of nasopharyngeal carcinoma.Methods The expression of CerbB-2 and COX-2 in 90 nasopharyngeal carcinoma tissues and 22 nasopharyngitis tissues was detected by SP immunohistochemical method.Results The positive expression rate of CerbB-2 and COX-2 protein in nasopharyngeal carcinoma tissues were 65.56% and 67.78%,respectively,and those in nasopharyngitis tissues were 31.82% and 36.36%,respectively,the difference was significant(P0.05).There was positivel correlation between the expression of CerbB-2 and COX-2 in nasopharyngeal carcinoma(r=0.526,P0.05).Conclusion These results demonstrated high expression of CerbB-2 and COX-2 may involve in the pathogenesis and progression of nasopharyngeal carcinoma.

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Available abstract

Objective To evaluate the relationship between the expression of CerbB-2 and COX-2 in nasopharyngeal carcinoma,and examine their possible effects on pathogenesis and progression of nasopharyngeal carcinoma.Methods The expression of CerbB-2 and COX-2 in 90 nasopharyngeal carcinoma tissues and 22 nasopharyngitis tissues was detected by SP immunohistochemical method.Results The positive expression rate of CerbB-2 and COX-2 protein in nasopharyngeal carcinoma tissues were 65.56% and 67.78%,respectively,and those in nasopharyngitis tissues were 31.82% and 36.36%,respectively,the difference was significant(P0.05).There was positivel correlation between the expression of CerbB-2 and COX-2 in nasopharyngeal carcinoma(r=0.526,P0.05).Conclusion These results demonstrated high expression of CerbB-2 and COX-2 may involve in the pathogenesis and progression of nasopharyngeal carcinoma.

Key concepts: Nasopharyngeal carcinoma, Immunohistochemistry, Pathogenesis, Medicine, Carcinoma, Oncology, Pathology, Cancer research

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Expression and relativity of CerbB-2,COX-2 in nasopharyngeal carcinoma — Research Paper | ScholarLens