Expression of p15 and nm23 Genes in Uterine Endometrial Carcinoma

Objective:To explore the role of p15 gene and nm23 gene in the generation and development of human uterine endometrial carcinoma.Methods:The expressions of p15 and nm23 were detected by immunohistochemistry S-P method in 60 specimens of uterine endometrial carcinoma and 10 specimens of normal endometrial tissues.The relation between the genes and the clinical pathology was studied in human uterine endometrial carcinoma.Results:The positive expression rates of p15 were significantly different between endometrial carcinoma and normal endometrial tissues(66.7% and 100%,P 0.01).The positive expression rates of nm23 were 60% and 70% between endometrial carcinoma and normal endometrial tissues(P 0.05).By chi-square test,the positive expression of p15 was significantly related with the pathological grades(P 0.05).The expression of nm23 was significantly related with operation-pathological stages and lymph node metastasis(P 0.05).By logistic regression analysis,there was positive correlation between the expression of p15 and pathological grades in endometrial carcinoma(OR=8.825,95%CI was 2.214-35.178,P 0.05).There was no correlation between the expression of nm23 and all the clinic-pathology parameters of uterine endometrial carcinoma.By rank correlation test,there was positive correlation between p15 expression and nm23 expression in the endometrial carcinoma(rs=0.754,P 0.01).Conclusion:The expression of p15 has an important meaning in judging prognosis evaluation of endometrial carcinoma.