The clinical value of glomerular filtration rate with ~(99m)Tc-DTPA on living kidney transplantation donors

Objective To determine the normal reference range of glomerular filtration rate (GFR)in different ages with 99mTc-DTPA renal dynamic imaging on living kidney transplantation donors,and to evaluate the clinical value of GFR in living kidney transplantation.Methods 99mTc-DTPA renal dynamic imaging was performed in 300 patients on living kidney transplantation donors.The imaginge was processed according to Gates' method to obtain GFR.The normal reference range of GFR was obtained in different ages and the relationship betwwen GFR and gender,age and body mass index was also analyzed.Results The left,right and total renal GFR of 300 living kidney transplantation donors were( 49.25±10.34)mL/min,(49.27±9.69)mL/min and (98.52±19.03)mL/min,respectively.The GFR in the group whose age50 was significantly higher than that in the qroup whose of age≥50(P0.05).There was no significant difference between the groups whose age50 and the qroup whose age≥50(P0.05).The study of logistic regression showed that the age was the only important impact factor on GFR.Conclusion GFR obtained by 99mTc-DTPA is simple and reliable,which can be used to accurately assess the individual renal filterability and the urinary drainage function.This offers a useful method for screening the living relative kidney transplantation donors.