Curative effect of aspirin combined with clopidogrel in the treatment of patients with progress cerebral arterial thrombosis and its influence on hs-CRP levels

Objective To investigate the curative effect of aspirin combined with clopidogrel in the treatment of patients with progress cerebral arterial thrombosis and its influence on hs-CRP levels.Methods 108 cases of patients with progress cerebral arterial thrombosis were randomly divided into two groups of 54 cases in each.The observation group used therapy aspirin combined with clopidogrel,control group used aspirin therapy,all for 15 d.Evaluated the clinical neurological defect degree and tested the level of serum hs-CRP before and after treatment,and the clinical efficacy and adverse reactions were observed after treatment.Results The difference of the degree of nerve function defect score and serum hs CRP level between two groups was statistically significant( P 0.05).Time on the degree of nerve function defect score and serum hs-influential CRP levels had a significant effect( P 0.05),no significant interaction between treatment method and time( P 0.05).The effect and the total effective rate of observation group were better than the control group( P 0.05).There was no statistically significant difference of adversereaction between two groups( P 0.05).Conclusion The nerve function and the curative effects of patients with progress cerebral arterial thrombosis who were treated with aspirin combined with clopidogrel were superior to aspirin alone,and the serum hs-CRP level significantly decreased.