The Research of the Expression and Significance of Bax、Bcl-XL in Articular Cartilage and Synovium of Osteoarthritic Animal Model

Objective To investigate the expression and significance of Bax、Bcl-XL in articular cartilage and synovium of osteoarthritic animal model. Methods Theleftknees of 24 rabbits were immobilized in full extension using plaster cast. Immunohistochemistry and TUNEL assay was used to detect the expression of Bax、Bcl-XL proteins in articular cartilage and synovium and the apoptosis of the articular chondrocytes and synovial cell of animal model. Results The positive expression rat of Bcl-XL protein in osteoarthritic synovium was higher than that in noral synovium (P 0.01). The positive expression rat of Bax protein in osteoarthritic chondrocytes was higher than that in normal chondrocytes (P 0.01). There was a positive correlation between degrees of the expression of Bax and chondrocytes apoptosis in osteoarthritic articular cartilage (P 0.01), but a negative correlateion between degree of the expression of Bcl-XL and chondrocytes apoptosis in osteoarthritic articular cartilage (P 0.05).Conclusion There was a consanguineous correlation between degrees of the expression of Bax Bcl-XL and chondrocytes apoptosis in osteoarthritic articular cartilage. It demonstrated that the abnormal expression of Bax, Bcl-XL closely related to the biological behaveior of OA such as occurrence, progress and so on.