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2005•Chinese Journal of Hospital PharmacyRequires access

Study on bioavailability and pharmacokinetics of nitrendipine nano-particles tablets in beagle dogs

Lantong Zhang

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Abstract

OBJECTIVE To establish an RP-HPLC method for determination of nitrendipine and to study the bioavailability and pharmacokinetics of nitrendipine nano-particle tablets in Beagle dogs.METHODS Twelve beagle dogs were devided into two groups at random and were given test and reference formulation,then plasma was taken at different times and was determined by RP-HPLC.The parameters of pharmacokinetics and bioavailability were caculated.RESULTS The parameters of the test and reference formulation:T_(peak)was((1.38)±(0.20))h and((1.87)±(0.22))h,C_(max)((110.1)±(14.0))μg·L~(-1)and((98.8)±(34.2))μg·L~(-1),AUC((684.1)±(96.6))μg·L~(-1)·h and((620.7)±(193.2))μg·L~(-1)·h respectively.CONCLUSION The absorption rate of nitrendipine nano-particle tablets was faster than that of the reference,so high blood pressure can be adjusted down rapidly due to higher bioavailability.

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OBJECTIVE To establish an RP-HPLC method for determination of nitrendipine and to study the bioavailability and pharmacokinetics of nitrendipine nano-particle tablets in Beagle dogs.METHODS Twelve beagle dogs were devided into two groups at random and were given test and reference formulation,then plasma was taken at different times and was determined by RP-HPLC.The parameters of pharmacokinetics and bioavailability were caculated.RESULTS The parameters of the test and reference formulation:T_(peak)was((1.38)±(0.20))h and((1.87)±(0.22))h,C_(max)((110.1)±(14.0))μg·L~(-1)and((98.8)±(34.2))μg·L~(-1),AUC((684.1)±(96.6))μg·L~(-1)·h and((620.7)±(193.2))μg·L~(-1)·h respectively.CONCLUSION The absorption rate of nitrendipine nano-particle tablets was faster than that of the reference,so high blood pressure can be adjusted down rapidly due to higher bioavailability.

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Available abstract

OBJECTIVE To establish an RP-HPLC method for determination of nitrendipine and to study the bioavailability and pharmacokinetics of nitrendipine nano-particle tablets in Beagle dogs.METHODS Twelve beagle dogs were devided into two groups at random and were given test and reference formulation,then plasma was taken at different times and was determined by RP-HPLC.The parameters of pharmacokinetics and bioavailability were caculated.RESULTS The parameters of the test and reference formulation:T_(peak)was((1.38)±(0.20))h and((1.87)±(0.22))h,C_(max)((110.1)±(14.0))μg·L~(-1)and((98.8)±(34.2))μg·L~(-1),AUC((684.1)±(96.6))μg·L~(-1)·h and((620.7)±(193.2))μg·L~(-1)·h respectively.CONCLUSION The absorption rate of nitrendipine nano-particle tablets was faster than that of the reference,so high blood pressure can be adjusted down rapidly due to higher bioavailability.

Key concepts: Beagle, Bioavailability, Nitrendipine, Pharmacokinetics, High-performance liquid chromatography, Pharmacology, Chemistry, Absorption (acoustics)

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