Clinical observation of plasma exchange and plasma perfusion on treating chronic hepatitis patients with severe jaundice

Objective To study the therapeutic effect of plasma exchange and plasma perfusion(PE+PP)on chronic hepatitis patients with severe jaundice. Methods Seventy-two patients with severe jaundice were divided into two groups randomly. In the treating group, the patients were treated with (PE+PP) on the basis of the conventional therapy, but the control group received the conventional therapy only. The main symptoms, liver function, prothrombin activity(PTA) before and 2 weeks, 4 weeks after treatment, were observed. Results After treating with (PE+PA), the liver function were ameliorated. The prothrombin activity increased significantly. 2 weeks, 4 weeks after treatment, the level of total bilirubin decreased markedly(P 0.01),the prothrombin activity increased significantly(P 0.05). The total effective rate in the treating group was 89.2%, while 71.4% in the control group. There were significant differences between the two group(sP 0.01). Conclusion Artificial liver support system can ameliorate the liver function of chronic with hepatitis patients severe jaundice. It can also increase the survival rate.